5 Best Mouse Poisons [2022 GUIDE]


Welcome to the best mouse poisons review and guide to help make your purchase decisions easier.

Most Effective Mouse Poison:

Just-One-Bite II Rat & Mouse Poison Bait

The poison bait is a second-generation anticoagulant that eliminates mice and rats – every time.

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Best Industrial Mouse Poison:

JT Eaton 754 Top Gun Pellet Rodenticide

The JT Eaton Top Gun is a close second to the Just-One_bite in the race for the most effective mouse poison title. These poison pellets come pre-packed in individual bags that you use as-is without a bait station.

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Best Indoor Mouse Poison:

JT Eaton 704-AP Apple Flavor Rodenticide Bait

Ditch the green, and go for the pink. These apple-flavored bait blocks are enticing to the mice and an excellent mouse exterminator in your home.

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Best Outdoor Mouse Poison:

Tomcat All-Weather Bait Chunx

The moisture-resistant bait blocks contain Diphacinone, the common active ingredient used in mouse control. Use them in bait stations to protect their efficacy.

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Best Fast-Acting Mouse Poison:

JT Eaton 716-S Nectus Soft Pest Bait

The soft and moist bait makes a high palatable food for mice. They are suitable for indoor and outdoor use in bait stations.

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Best Pet Safe Mouse Poison:

JT Eaton 754 Top Gun Pellet Rodenticide

The poison contains Bitrex, a bitter substance that repels other animals and prevents consumption by small children. It is still best to set the bait where the mice frequent, but your pet cannot reach it.

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Best Mouse Poison Pellets:

JT Eaton 754 Top Gun Pellet Rodenticide

The pelleted bait contains Bromethalin and is an effective neurological poison that attacks the mouse’s central nervous system.

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Best Mouse Poison Bait Station:

Protecta LP Rat Bait Stations

It is a pack of 6 bait stations with a low profile design to fit hard-to-reach places and is easy to open but lock securely.

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#1 Just-One-Bite II Rat & Mouse Poison Bait

There are many mouse poisons on the market, and choosing one that works effectively and consistently can be challenging.

What is the most effective mouse poison?

Look no further than the mouse poison bars by Just-One-Bite.

It contains Bromadiolone – a second-generation anticoagulant that kills small to mid-sized rodents, including those resistant to warfarin and first-generation anticoagulants.

It kills giant Norway rats, so you can be sure the smaller mice will not survive the poison.

The 1 pound bars are tough – insert the bar in a bag and break it into smaller pieces with a hammer to control the bait portion.

What you get with this mouse poison:

  • Bromadiolone active ingredient.
  • Kills house mice, roof rats, and Norway rats in a single feeding.
  • Kills warfarin-resistant rats, so it is a surefire way to kill mice.
  • 8x individually wrapped 1-lb bars.


  • Nothing notable.

#2 JT Eaton 754 Top Gun Pellet Rodenticide

The JT Eaton Top Gun is a non-anticoagulant poison containing Bromethalin – a neurotoxin that affects brain cells and causes swelling in the central nervous system.

The horror description aside, it is lethal for mice and a product you can depend on to perform its job.

You set the bait with the pellets packaged in the plastic bag, so no bait station is needed. The mice will chew through the bag to access the bait.

For large commercial and industrial properties, the baiting method ensures speed and ease of application. It avoids needing to come into contact with the poison bait in a hassle-free setup.

The pellets contain Bitrex, a substance so bitter it deters accidental consumption by children, so you can feel safe using it around your home.

Still, place the bait bags in hard-to-reach places that only mice can access.

What you get with this mouse poison:

  • Bromethalin active ingredient.
  • Contains Bitrex – deters consumption by children.
  • 128 packs of 0.5-ounce bait pellets.


  • Feeding the bait in the bags may not always attract mice.

#3 JT Eaton 704-AP Apple Flavor Rodenticide Bait

Most mouse poisons on the market contain Diphacinone and are manufactured in green blocks.

If you find your current supply of mouse bait not enticing enough for the mice, switching to this apple-flavored attractant may do the trick.

Each bait block has a hole in the center, so you can use it with any bait station, bought or DIY.

You set the poison in a bait station to protect your pet and non-target wildlife from accessing it when used indoor or outdoor.

What you get with this mouse poison:

  • Diphacinone active ingredient.
  • Apple-flavored scent.
  • 64 blocks in a pail, 1-ounce each.
  • Each block has a hole in the center – compatible with most bait stations.


  • It may become less effective over time, in which case you need to switch to a bromethalin-based rodenticide.

#4 Tomcat All-Weather Bait Chunx

When setting mouse bait outdoors, you need a product that does not lose its efficacy when unprotected from rain and moisture.

The bait blocks are moisture-resistant, but the best baiting method of using a bait station remains. It is practical to keep non-target wildlife away from the poison and maintain the bait’s efficacy for longer.

The blocks contain food-grade ingredients and enhancers that mice would find irresistible.

But if you find that your current supply of Diphacinone poison has become ineffective against mice, go with #1 Just-One-Bite or #2 JT Eaton Top Gun. Their active ingredients are generally more potent.

What you get with this mouse poison:

  • Diphacinone active ingredient (not Bromadiolone).
  • Mold and moisture-resistant.
  • Suitable for outdoor use.
  • 4-lb pail.


  • Diphacinone is not as strong a killer as bromadiolone active ingredient.

#5 JT Eaton 716-S Nectus Soft Pest Bait

These Nectus soft bait bags are an excellent poison snack for pesky mice that are ruining your property. Unlike the traditional bait blocks that are tough, the moist bait is highly palatable to small and mid-sized rodents.

Each bag is individually packed for convenience and ease of application. Stick the bait station’s internal rod through the bait bags, and lock the station. Check the station daily and replenish the bait as needed.

The second-generation Bromadiolone active ingredient gets rid of mice effectively. It eliminates large Norway rats, so you can be sure it will kill mice that are half the size.

Further, the bait can withstand extreme heat and cold, dry or wet.

What you get with this mouse poison:

  • Bromadiolone active ingredient.
  • Contains soft and moist bait in individually packed bags.
  • Contains Bitrex – bitter.
  • 16-lb pail.
  • Kills warfarin-resistant large rats.


  • More expensive than other baits for the same result.

#6 Protecta LP Rat Bait Stations

The low-profile bait station design has chamfered corners that fit wall corners along the mice’s path.

It holds dry and liquid bait. The station does not come with bait, but any of the mouse poison in this post will make an excellent bait to help you get rid of your mouse problem.

The bait station opens and locks securely, and loading and replenishing the bait are equally effortless.

Note that every purchase comes with 6 bait stations but only 1 key.

What you get with this bait station:

  • 6 bait stations, 1 key.
  • Triangular design that fits corners better.
  • For indoor and outdoor use.
  • Holds dry and liquid bait.
  • Bait is not included.


  • It can be hard to open (but good if you want to protect your child or pet from the bait)

Mouse Poison Guide

Poison baits are an effective method to get rid of mice around your home, but as with any harmful substance, you need to use and store them safely to avoid causing harm to other non-target animals.

Are Rat and Mouse Poison the Same?

Mice and rats are common household rodents that can cause physical destruction to homes and spread diseases.

Their colonies multiply rapidly, and you need to exterminate them as soon as you discover a rodent problem in and around your house.

The poison baits used for rats and mice are the same, commonly available as the anticoagulant or non-anticoagulant type. Their active ingredients can be Diphacinone, Bromadiolone, or Bromethalin. Rats are generally twice the mice’s size and weight. Effective rat poison can kill mice, but you need a more potent poison or larger dosage to kill rats.

Types of Mouse Poison

Mouse poison baits come in block or pellet forms, although the former is more readily available on the market.

The baits are mostly of the anticoagulant type, which prevents blood clotting and causes internal hemorrhaging, killing the mouse after several days. On the other hand, non-anticoagulant mouse poisons kill mice with less bait and a shorter time.

What is the Active Ingredient in Mouse Poison?

Manufacturers use various types of active ingredients as the killing agent in poison baits.

The common active ingredients in mouse poison include:

  • Diphacinone – anticoagulant (most common).
  • Bromadiolone – anticoagulant.
  • Warfarin – anticoagulant.
  • Bromethalin – non-anticoagulant.
  • Cholecalciferol – non-anticoagulant.
  • Zinc phosphide – non-anticoagulant.

Where to Place Mouse Bait Stations?

If the bait’s smell is enticing enough, the mouse will have no difficulty locating it. But you want to identify the places that can give you results quicker, indoors or outdoors.

Place the mouse bait stations strategically where the mice can easily find the poison bait. These places include:

  • Near their burrows.
  • Along their travel routes.
  • Where you spotted mouse urine and droppings.
  • The gap in the wall they use to enter the house.
  • Always place them against the wall and under the cabinet (or places) where your cat or dog cannot access.

How Often Should You Change Mouse Bait?

Your bait may or may not attract mice, but if it does, you want to ensure they have a continuous supply of poison to kill them in the shortest time possible.

Not all attractants are potent, so you also want to know if you bought the right product to eliminate your mice problem.

Check and replenish the bait as needed daily for up to 2 weeks or until you notice reduced mouse activity. If the bait is left untouched after one night, relocate the bait. But if baiting continues to fail, you need to switch to a different bait.

Where Do Mice Die After Eating Poison?

Anticoagulant and non-anticoagulant poison baits do not kill the mouse until several days later.

The mice consume the poison and leave the bait station. They could die in any place apart from where you set the bait – yard, burrow, attic, or cavity wall. If you do not see dead mice with the reduction in mouse activity, try locating the path they usually take. Otherwise, no smell or sight of dead carcasses means the mice probably died in their burrow.

Why is the Mouse Not Eating the Poison?

Not all rodenticides are effective for the type of rodent problem you have around your home.

Further, product design, manufacturing quality, and storage conditions can affect how well the poison does what it should do.

Efficacy aside, the mice in your home may not find the poison bait attractive for several reasons, including a less-than-alluring smell or an old batch nearing or past its expiry. You can coat a layer of peanut butter on the bait blocks to make them irresistible for the mice to gnaw on.

Is Mouse Poison Safe for Pets?

The active ingredients in rodenticides attack the animal’s nervous system and cause internal bleeding, resulting in a slow death that takes several days.

The poison is fatal to rodents, although how quickly it kills depends on the bait’s potency and the amount consumed.

Rodenticides are non-discriminatory killers. If cats, dogs, or birds consume rat or mouse poison, the adverse effect on their body is the same but slower relative to their size, which is why baiting in a secure and enclosed station is advisable. If you notice or suspect your pet has ingested rodent poison, bring it to the vet immediately.

What About the Other Animals?

Rodent poison manufacturers will not indicate the non-target animals outside their products’ design, but it does not mean the poison won’t be lethal to them.

Rodenticides can kill most animals of a similar size to house mice and rats if they consume the poison in the right amount. They include:

  • Shrews.
  • Voles.
  • Moles.
  • Gophers.
  • Groundhogs.
  • Chipmunks.
  • Squirrels.
  • Rabbits.
  • Small cats.
  • Birds.
  • Chickens.

The poison can be lethal, but the product design may not attract those animals the way it does mice and rats.